Cheryl Johnson, 59, of Bronx, N.Y., was pronounced dead at the scene, while Cecilia Kiyanitza, 66, of Woodbury, N.J. was airlifted to an area hospital where she was later pronounced dead.
The bus, carrying about 20 passengers, was heading south when it collided with a pickup truck on the outer roadway at milepost 93.1 in Woodbridge, New Jersey State Police said.
The driver of the bus, a 56-year-old male of Westville, N.J., sustained serious injuries. No injuries were reported to the driver of the Ford F-150 pickup.
Fourteen passengers sustained non-life-threatening injuries, and four passengers sustained no injuries.
The bus went off the road to the right and overturned onto the entrance ramp to the Thomas Edison Service Area.
This is a developing story.
Click here to follow Daily Voice Bergenfield and receive free news updates.